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dc.contributor.authorO'FARRELLY, CLIONAen
dc.contributor.authorLYNCH, LYDIAen
dc.date.accessioned2013-07-09T14:34:51Z
dc.date.available2013-07-09T14:34:51Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationO'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE, 5, 4, 2010, art. no. e9997en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/66671
dc.descriptionPUBLISHEDen
dc.descriptionPubMed ID: 20376319en
dc.description.abstract12 Hide Figures Abstract Introduction Methods Results Discussion Author Contributions References Reader Comments (0) Figures Abstract Objective Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible for this phenomenon. We proposed that adipocyte size might be a key factor in the protection of metabolically healthy obese (MHO) individuals from the adverse effects of obesity. Subjects Thirty-five patients undergoing bariatric surgery were classified as MHO (n = 15) or metabolically unhealthy obese (MUO, n = 20) according to cut-off points adapted from the International Diabetes Federation definition of the metabolic syndrome. Median body mass index (BMI) was 48 (range 40?71). Results There was a moderate correlation between omental adipocyte size and subcutaneous adipocyte size (r = 0.59, p<0.05). The MHO group had significantly lower mean omental adipocyte size (80.9?10.9 ?m) when compared with metabolically unhealthy patients (100.0?7.6 ?m, p<0.0001). Mean subcutaneous adipocyte size was similar between the two groups (104.1?8.5 ?m versus 107.9?7.1 ?m). Omental, but not subcutaneous adipocyte size, correlated with the degree of insulin resistance as measured by HOMA-IR (r = 0.73, p<0.0005), as well as other metabolic parameters including triglyceride/HDL-cholesterol ratio and HbA1c. Twenty-eight patients consented to liver biopsy. Of these, 46% had steatohepatitis and fibrosis. Fifty percent (including all the MHO patients) had steatosis only. Both omental and subcutaneous adipocyte size were significantly associated with the degree of steatosis (r = 0.66, p<0.0001 and r = 0.63, p<0.005 respectively). However, only omental adipocyte size was an independent predictor of the presence or absence of fibrosis. Conclusion Metabolically healthy individuals are a distinct subgroup of the severely obese. Both subcutaneous and omental adipocyte size correlated positively with the degree of fatty liver, but only omental adipocyte size was related to metabolic health, and possibly progression from hepatic steatosis to fibrosis.en
dc.description.sponsorshipThis work was supported by a clinical fellowship from the Irish Health Research Board and an award from the Medical Research Charities Group and Diabetes Federation of Ireland. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extentart. no. e9997en
dc.language.isoenen
dc.relation.ispartofseriesPLoS ONEen
dc.relation.ispartofseries5en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectsubcutaneous adipocyteen
dc.subject.lcshsubcutaneous adipocyteen
dc.titleThe relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesityen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ofarreclen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lynchl3en
dc.identifier.rssinternalid87057en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0009997en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen


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