N1-dansyl-spermine: a potent polyamine antagonist.
Item Type:Journal Article
Citation:Kirby BP, Ryder SA, Seiler N, Renault J, Shaw GG., N1-dansyl-spermine: a potent polyamine antagonist., Brain Res., 1011, 1, 2004, 69-73
Kirby_Ryder_Seiler_Renault_Shaw_2004_N1-dansyl-spermine_a_potent_polyamine_antagonist.pdf (Published (author's copy) - Peer Reviewed) 560.4Kb
The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine (100 ?g, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic convulsions). In addition, the same dose of N1-dansyl-spermine antagonised spermine's enhancement of NMDA-induced convulsions. These results suggest that N1-dansyl-spermine is in vivo a potent antagonist of the CNS effects of spermine and of its action at the positive polyamine modulatory site on the NMDA receptor.
Author: RYDER, SHEILA
Type of material:Journal Article
Series/Report no:Brain Res.
Availability:Full text available
Keywords:Spermine, N-methyl-D-aspartate, N1-dansylspermine, Convulsion, Spermine, Polyamine, Excitotoxicity