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dc.contributor.authorMILLINGTON-WARD, SOPHIA
dc.contributor.authorCHADDERTON, NAOMI SARAH
dc.contributor.authorFARRAR, GWYNETH JANE
dc.contributor.authorKENNA, PAUL
dc.date.accessioned2013-07-08T14:41:19Z
dc.date.available2013-07-08T14:41:19Z
dc.date.issued2013
dc.date.submitted2013en
dc.identifier.citationFarrar, G.J., Chadderton, N., Kenna, P.F., Millington-Ward, S, Mitochondrial disorders: aetiologies, models systems, and candidate therapies, Trends in Genetics, 2013, 00-00en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/66646
dc.descriptionIN_PRESSen
dc.description.abstractIt has become evident that many human disorders are characterised by mitochondrial dysfunction either at a primary level, due to mutations in genes whose encoded products are involved in oxidative phosphorylation, or at a secondary level, due to the accumulation of mitochondrial DNA (mtDNA) mutations. This has prompted keen interest in the development of cell and animal models and in exploring innovative therapeutic strategies to modulate the mitochondrial deficiencies observed in these diseases. Key advances in these areas are outlined in this review, with a focus on Leber hereditary optic neuropathy (LHON). This exciting field is set to grow exponentially and yield many candidate therapies to treat this class of disease.en
dc.description.sponsorshipOur work has been supported by Science Foundation Ireland, the Health Research Board of Ireland, Fighting Blindness Ireland, Foundation Fighting Blindness USA (NNRI), the Wellcome Trust, the European framework programme EviGenoRet, Enterprise Ireland and the Irish Research Council for Science, Engineering and Technologyen
dc.format.extent00-00en
dc.language.isoenen
dc.relation.ispartofseriesTrends in Genetics;
dc.rightsYen
dc.subjectgene therapy; Leber hereditary optic neuropathy; mitochondrial diseaseen
dc.subject.lcshgene therapy; Leber hereditary optic neuropathy; mitochondrial diseaseen
dc.titleMitochondrial disorders: aetiologies, models systems, and candidate therapiesen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gjfarrar
dc.identifier.peoplefinderurlhttp://people.tcd.ie/millins
dc.identifier.peoplefinderurlhttp://people.tcd.ie/chaddern
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pfkenna
dc.identifier.rssinternalid86794


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