A family of cyclophilin-like molecular chaperones in Plasmodium falciparum
Citation:
Marin-Menendez A, Monaghan P, Bell A, A family of cyclophilin-like molecular chaperones in Plasmodium falciparum, Molecular & Biochemical Parasitology, 184, 2012, 44 - 47Download Item:
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Abstract:
The cyclophilins are a large family of proteins implicated in folding, transport and regulation of other proteins and are potential drug targets in cancer and in some viral and parasitic infections. The functionality of cyclophilins appears to depend on peptidyl-prolyl cis-trans isomerase (foldase) and/or molecular chaperone activities. In this study we assessed the peptidyl-prolyl isomerase and chaperone activities of 8 members of the Plasmodium falciparum cyclophilin family, all produced recombinantly using a common host/vector system. While only two of these proteins had isomerase activity, all of them displayed chaperone function as judged by the ability to prevent the thermal aggregation of model substrates. We suggest that the cyclophilins constitute a family of molecular chaperones in malarial parasites that complement the functions of other chaperones such as the heat-shock proteins.
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http://people.tcd.ie/abellhttp://people.tcd.ie/marinmea
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Author: MARIN MENENDEZ, ALEJANDRO; BELL, ANGUS
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Molecular & Biochemical Parasitology;184;
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