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dc.date.accessioned2012-06-18T14:15:07Z
dc.date.available2012-06-18T14:15:07Z
dc.date.createdMay 2011en
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationF. Wetterling, L. Gallagher, W. Holmes, I. M. MacRae, and A. J. Fagan, Temporal water mobility and sodium intensity measurements in penumbra and core tissue during acute stroke, International Society for Magnetic Resonance in Medicine, Montreal, May 2011, 2011, 470-en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/63765
dc.descriptionPUBLISHEDen
dc.descriptionMontrealen
dc.description.abstractThe perfusion-diffusion mismatch is a commonly used approach to distinguish between still-viable penumbra and irreversibly damaged core tissue in human stroke patients. However, in recent years it has become clear that the diffusion lesion does not accurately identify infarcted tissue, casting doubt on the validity of the perfusion-diffusion mismatch approach. Sodium-MRI (Na-MRI) can offer an alternative approach to identifying tissue at risk of infarction. The aim of this study was to investigate the hypothesis that an increase in 23Na signal above normal levels indicates tissue destined for infarction [1]. To do this, the timecourse evolution of Apparent Diffusion Coefficient (ADC) and 23Na signal changes during the acute phase of a rodent stroke model was measured, differentiating between penumbral and core tissue through the use of both the perfusion deficit measured immediately before the animals were sacrificed (~5hrs after stroke) and the subsequent histologically-determined regions of infarcted tissue.en
dc.description.sponsorshipScience Foundation Irelanden
dc.format.extent470en
dc.language.isoenen
dc.rightsYen
dc.subjectSodium-MRIen
dc.subjectStrokeen
dc.subjectPenumbraen
dc.titleTemporal water mobility and sodium intensity measurements in penumbra and core tissue during acute strokeen
dc.title.alternativeInternational Society for Magnetic Resonance in Medicineen
dc.typeMeeting Abstracten
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fagananen
dc.identifier.rssinternalid77290en
dc.contributor.sponsorGrantNumber06/RFP/PHY006en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDThemeNext Generation Medical Devicesen


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