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dc.contributor.authorCONNOR, THOMAS JOSEPH
dc.date.accessioned2012-02-29T12:38:25Z
dc.date.available2012-02-29T12:38:25Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationD.M. Kerr, N.N. Burke, G.K. Ford, T.J. Connor, B. Harhen, L.J. Egan, D.P. Finn, M. Roche, Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor, Neuroscience, 204, 2012, 53 - 63en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/62415
dc.descriptionPUBLISHEDen
dc.description.abstractThe endocannabinoid system is an important regulator of the nervous, neuroendocrine and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, there is a paucity of data relating to the effects of endocannabinoids on neuroinflammatory mediators following an immune stress/challenge in vivo. This study investigated the effects of URB597, a selective inhibitor of fatty acid amine hydrolyase (FAAH), the enzyme that preferentially metabolises anandamide, on lipopolysaccharide (LPS)-induced increases in the expression of immune mediators in the hypothalamus. Systemic administration of URB597 increased the levels of anandamide and the related N -acylethanolamines, N -palmitoyl ethanolamide and N-oleoyl ethanolamide, but not 2-arachidonoyl glycerol, in the hypothalamus and spleen. URB597 attenuated the LPS-induced increase in interleukin (IL)-1? expression while concurrently augmenting the LPS-induced increase in suppressor of cytokine signalling (SOCS)-3 expression. In addition, URB597 tended to enhance and reduce the LPS-induced increase in IL-6 and IL-10 mRNA expression respectively. LPS-induced increases in peripheral cytokine levels or plasma corticosterone were not altered by URB597. The present study provides evidence for a role for FAAH in the regulation of LPS-induced expression of inflammatory mediators in the hypothalamus. Improved understanding of endocannabinoid-mediated regulation of neuroimmune function has fundamental physiological and potential therapeutic significance in the context of stress-related disorders.en
dc.format.extent53en
dc.format.extent63en
dc.language.isoenen
dc.relation.ispartofseriesNeuroscience;
dc.relation.ispartofseries204;
dc.rightsYen
dc.subjectNeuroscienceen
dc.subjectImmunologyen
dc.subjectEndocannabinoiden
dc.subjectanandamideen
dc.titlePharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressoren
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/connort
dc.identifier.rssinternalid75026
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.neuroscience.2011.09.032en


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