A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
Citation:
Niko Radulović, Nevenka Đorđević, Marija Denić, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio Boylan, A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity, Food and Chemical Toxicology, 50, 2, 2012, 274 279Download Item:
A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae)- identification, synthesis and antinociceptive activity.pdf (Published (publisher's copy) - Peer Reviewed) 608.1Kb
Abstract:
2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin?s strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20 mg/kg). It was found to be lethal in doses higher than 20 mg/kg.
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http://people.tcd.ie/desouzafDescription:
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Author: DE SOUSA MENEZES, FABIO
Type of material:
Journal ArticleSeries/Report no:
Food and Chemical Toxicology50
2
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Full text availableSubject (TCD):
Immunology, Inflammation & Infection , International DevelopmentLicences: