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dc.contributor.authorPRENDERGAST, PATRICKen
dc.date.accessioned2012-01-12T14:26:04Z
dc.date.available2012-01-12T14:26:04Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationP.J. Prendergast, P.E. Galibarov, C. Lowrey, A.B. Lennon, Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis, Journal of the Mechanical Behavior of Biomedical Materials, 4, 8, 2011, 1880 1887en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/61633
dc.descriptionPUBLISHEDen
dc.description.abstractComputational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted in an idealized or `average? patient; we present here a method for predicting the performance of an orthopaedic implant when released into a population?effectively simulating a clinical trial. Specifically we hypothesise an analysis based on a method for predicting the performance in a population will lead to different conclusions than an analysis based on an idealised or `average? patient. To test this hypothesis we use a finite element model of an intramedullary implant in a bone whose size and remodelling activity is different for each individual in the population. We compare the performance of a low Young?s modulus implant () to one with a higher Young?s modulus (200 GPa). Cyclic loading is applied and failure is assumed when the migration of the implant relative to the bone exceeds a threshold magnitude. The analysis in an idealized of `average? patient predicts that the lower modulus device survives longer whereas the analysis simulating a clinical trial predicts no statistically-significant tendency (p=0.77) for the low modulus device to perform better. It is concluded that population-based simulations of implant performance?simulating a clinical trial?presents a very valuable opportunity for more realistic computational pre-clinical testing of medical devices.en
dc.format.extent1880-1887en
dc.language.isoenen
dc.relation.ispartofseriesJournal of the Mechanical Behavior of Biomedical Materialsen
dc.relation.ispartofseries4en
dc.relation.ispartofseries8en
dc.rightsYen
dc.subjectBioengineeringen
dc.subjectSimulated clinical trialsen
dc.subjectIntramedullary fixationen
dc.subjectStochastic modelen
dc.subjectFinite element analysisen
dc.subjectMechanobiologyen
dc.titleComputer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesisen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pprenderen
dc.identifier.rssinternalid73734en
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.jmbbm.2011.06.005en


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