Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats.
Item Type:Journal Article
Citation:Passecker J, Hok V, Della-Chiesa A, Chah E, O'Mara SM, Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats., Frontiers in Behavioral Neuroscience, 5, 2011, 66-
Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats.pdf (Published (publisher's copy) - Peer Reviewed) 1.129Mb
Stress has deleterious effects on brain, body, and behavior in humans and animals alike. The present work investigated how 30-min acute photic stress exposure impacts on spatial information processing in the main sub-regions of the dorsal hippocampal formation [CA1, CA3, and dentate gyrus (DG)], a brain structure prominently implicated in memory and spatial representation. Recordings were performed from spatially tuned hippocampal and DG cells in rats while animals foraged in a square arena for food. The stress procedure induced a decrease in firing frequencies in CA1 and CA3 place cells while sparing locational characteristics. In contrast to the CA1-CA3 network, acute stress failed to induce major changes in the DG neuronal population. These data demonstrate a clear dissociation of the effects of stress on the main hippocampal sub-regions. Our findings further support the notion of decreased hippocampal excitability arising from behavioral stress in areas CA1 and CA3, but not in DG.
Science Foundation Ireland (SFI)
Type of material:Journal Article
Series/Report no:Frontiers in Behavioral Neuroscience
Availability:Full text available