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dc.contributor.authorFINLAY, DAVIDen
dc.date.accessioned2011-11-02T12:19:06Z
dc.date.available2011-11-02T12:19:06Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationFinlay DK, Cantrell DA, Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration., Annals of the New York Academy of Sciences, 1183, 2010, 149-57en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/60446
dc.descriptionPUBLISHEDen
dc.description.abstractThe established role for phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3) signaling pathways is to regulate cell metabolism. More recently it has emerged that PI(3,4,5)P3 signaling via mammalian target of rapamycin and Foxo transcription factors also controls lymphocyte trafficking by determining the repertoire of adhesion and chemokine receptors expressed by T lymphocytes. In quiescent T cells, nonphosphorylated active Foxos maintain expression of KLF2, a transcription factor that regulates expression of the chemokine receptors CCR7 and sphingosine 1 phosphate receptor, and the adhesion receptor CD62L that together control T-cell transmigration into secondary lymphoid tissues. PI(3,4,5)P3 mediates activation of protein kinase B, which phosphorylates and inactivates Foxos, thereby terminating expression of KLF2 and its target genes. The correct localization of lymphocytes is essential for effective immune responses, and the ability of phosphoinositide 3-kinase and mammalian target of rapamycin to regulate expression of chemokine receptors and adhesion molecules puts these signaling molecules at the core of the molecular mechanisms that control lymphocyte trafficking.en
dc.format.extent149-57en
dc.language.isoenen
dc.relation.ispartofseriesAnnals of the New York Academy of Sciencesen
dc.relation.ispartofseries1183en
dc.rightsYen
dc.subjectImmunologyen
dc.subjectT cellsen
dc.titlePhosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/finlayden
dc.identifier.rssinternalid75603en
dc.identifier.doihttp://dx.doi.org/10.1111/j.1749-6632.2009.05134.xen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://dx.doi.org/10.1111/j.1749-6632.2009.05134.xen


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