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dc.contributor.authorREYNOLDS, JOHN
dc.contributor.authorDONOHOE, CLAIRE
dc.date.accessioned2011-08-29T09:36:03Z
dc.date.available2011-08-29T09:36:03Z
dc.date.issued2011
dc.date.submitted2011en
dc.identifier.citationClaire L. Donohoe, Aoife M. Ryan, and John V. Reynolds, Cancer Cachexia:Mechanisms and Clinical Implications, Gastroenterology Research and Practice, 2011, 601434, 2011, 13en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/59126
dc.descriptionPUBLISHEDen
dc.description.abstractCachexia is amultifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate). Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated. Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling themin the clinical setting. Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.en
dc.format.extent13en
dc.language.isoenen
dc.publisherHindawien
dc.relation.ispartofseriesGastroenterology Research and Practice;
dc.relation.ispartofseries2011;
dc.relation.ispartofseries601434;
dc.rightsYen
dc.subjectOncologyen
dc.subjectCachexiaen
dc.titleCancer Cachexia:Mechanisms and Clinical Implicationsen
dc.contributor.sponsorIrish Cancer Societyen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/reynoljv
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cdonohue
dc.identifier.rssinternalid73850
dc.identifier.rssurihttp://dx.doi.org/10.1155/2011/601434en


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