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dc.contributor.authorMc Lysaght, Aoifeen
dc.date.accessioned2011-08-16T14:13:27Z
dc.date.available2011-08-16T14:13:27Z
dc.date.issued2008en
dc.date.submitted2008en
dc.identifier.citationAoife McLysaght, Evolutionary steps of sex chromosomes are reflected in retrogenes, Trends in Genetics, 24, 10, 2008, 478 - 481en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/58714
dc.descriptionPUBLISHEDen
dc.description.abstractIt has been shown that selective pressure to compensate for the silencing of the sex chromosomes during male meiosis resulted in many X-linked genes being duplicated as functional retrogenes on autosomes. Sex chromosome silencing in males was probably stratified during evolution, in accordance with the stratified diversification of the sex chromosomes. Here I show that the timing of the retrocopying events is associated with the timing of the X-Y differentiation of the region of X chromosome housing the parental copy of the gene.en
dc.description.sponsorshipI thank Henrik Kaessmann for helpful discussion and a critical appraisal of this manuscript. I also thank Mario Fares, Andrew Lloyd and Ken Wolfe for useful comments. This work is supported by Science Foundation Ireland (SFI).en
dc.format.extent478en
dc.format.extent481en
dc.language.isoenen
dc.relation.ispartofseriesTrends in Geneticsen
dc.relation.ispartofseries24en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectGeneticsen
dc.subjectX-Y differentiationen
dc.titleEvolutionary steps of sex chromosomes are reflected in retrogenesen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclysagaen
dc.identifier.rssinternalid53033en
dc.subject.TCDThemeGenes & Societyen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.tig.2008.07.006en
dc.identifier.orcid_id0000-0003-2552-6220en


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