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dc.contributor.authorJOHNSON, KATHERINEen
dc.contributor.authorBARRY, EDWINAen
dc.contributor.authorROBERTSON, IANen
dc.contributor.authorGARAVAN, HUGHen
dc.contributor.authorHAWI, ZIARIHen
dc.contributor.authorMULLIGAN, AISLINGen
dc.contributor.authorGILL, MICHAELen
dc.date.accessioned2011-04-01T15:10:05Z
dc.date.available2011-04-01T15:10:05Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationW Braet, KA Johnson, CT Tobin, R Acheson, C McDonnell, Z Hawi, E Barry, A Mulligan, M Gill, MA Bellgrove, IH Robertson, H Garavan, fMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD, Neuropsychologia, 49, 7, 2011, 1641-1650en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/54419
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 21232548en
dc.description.abstractThe DAT1 gene codes for the dopamine transporter, which clears dopamine from the synaptic cleft, and a variant of this gene has previously been associated with compromised response inhibition in both healthy and clinical populations. This variant has also been associated with ADHD, a disorder that is characterised by disturbed dopamine function as well as problems with response inhibition. In the present study we used fMRI to investigate the role of dopaminergic genetic variation on executive functioning by comparing how activation associated with successful and unsuccessful inhibitions differs based on DAT1-genotype and ADHD-diagnosis in adolescents performing a go/nogo task. The results identify regional specificity concerning which functional differences can be attributed to the possession of the high risk DAT1 genotype, the clinical condition or an interaction between the two. During response inhibition, individuals with two copies of the 10-repeat allele showed increased activation in frontal, medial, and parietal regions, which may indicate that inhibition is more effortful for this group. Conversely, this group displayed a reduced error response in the parahippocampal gyrus, suggestive of reduced learning from errors. There were also a number of frontal, parietal, medial and occipital regions, where the relationship between genotype and fMRI-activation differed between the ADHD group and typically developing adolescents. Finally, the ADHD group displayed decreased activation in parietal and (pre)frontal regions during response inhibition, and in frontal and medial brain regions on error trials.en
dc.description.sponsorshipThis study was supported by grants from the Science Foundation Ireland, the Irish Health Research Board, the Irish Higher Education Authority's Programme for Research in Third-Level Institutions, the Australian National Health and Medical Research Council Howard Florey Centenary Fellowship, and the FWO Research Foundation - Flanders. Data-analysis was performed on computers of the Trinity Centre for High Performance Computing. The authors would like to thank all participants, as well as their parents.en
dc.format.extent1641-1650en
dc.language.isoenen
dc.relation.ispartofseriesNeuropsychologiaen
dc.relation.ispartofseries49en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectNeuroscienceen
dc.subjectADHDen
dc.subjectDAT1en
dc.titlefMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHDen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorHigher Education Authority (HEA)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/irobertsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zhhawien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/johnsokaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanhen
dc.identifier.rssinternalid70250en
dc.identifier.doihttp://dx.doi.org/10.1016/j.neuropsychologia.2011.01.001en
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.neuropsychologia.2011.01.001en


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