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dc.contributor.authorMAC ANANEY, OSCARen
dc.contributor.authorREILLY, HEATHERen
dc.contributor.authorEGANA, MIKELen
dc.date.accessioned2011-02-22T15:27:07Z
dc.date.available2011-02-22T15:27:07Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationMacAnaney O, Reilly H, O'Shea D, Ega?a M and Green S, Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise, Diabetes and Vascular Disease Research, 8, 1, 2011, 12 - 21en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/50746
dc.descriptionPUBLISHEDen
dc.description.abstractIn this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = 10) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 ? 29.2 s) than the heavy (22.2 ? 13.4 s) and lean (21.8 ? 9.3 s) controls, resulting in a significantly greater MRT in the diabetic group (median [IQR] = 30.7 [24.6?46.5] s versus 16.3 [4.3?23.2] s and 18.4 [13.7?19.3] s). These data support the hypothesis and suggest that a slowed hyperaemic response in the exercising limb might contribute to exercise intolerance in diabetic subjects.en
dc.format.extent12en
dc.format.extent21en
dc.language.isoenen
dc.relation.ispartofseriesDiabetes and Vascular Disease Researchen
dc.relation.ispartofseries8en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectPhysiologyen
dc.subjecttype 2 diabetesen
dc.titleEffect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exerciseen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/meganaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/macanaoen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/hereillyen
dc.identifier.rssinternalid68911en
dc.identifier.rssurihttp://dx.doi.org/10.1177/1479164110389625en


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