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dc.contributor.authorGRAY, STEVENen
dc.contributor.authorLAWLESS, MATTHEWen
dc.contributor.authorKELLEHER, DERMOTen
dc.contributor.authorMANKAN, ARUN KUMARen
dc.contributor.authorMCMANUS, ROSSen
dc.date.accessioned2011-02-17T22:29:43Z
dc.date.available2011-02-17T22:29:43Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationMankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine, 13, 4, 2009, 631-643en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/50657
dc.descriptionPUBLISHEDen
dc.description.abstractNuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological processes including innate and adaptive immunity, inflammation, cellular stress responses, cell adhesion, apoptosis and proliferation. Appropriate regulation of NF-?B is critical for the proper function and survival of the cell. Aberrant NF-?B activity has now been implicated in the pathogenesis of several diseases ranging from inflammatory bowel disease to autoimmune conditions such as rheumatoid arthritis. Systems governing NF-?B activity are complex and there is an increased understanding of the importance of nuclear events in regulating NF-?B's activities as a transcription factor. A number of novel nuclear regulators of NF-?B such asI?B-? and PDZ and LIM domain 2 (PDLIM2) have now been identified, adding another layer to the mechanics of NF-?B regulation. Further insight into the functions of these molecules raises the prospect for better understanding and rational design of therapeutics for several important diseases.en
dc.description.sponsorshipThe authors wish to acknowledge support from Wellcome Trust/ HRB "New Blood" Fellowship, Science Foundation Ireland and Higher Education Authority PRTLI. The authors wish to thank Serkan ?smail Goktuna for the artwork.en
dc.format.extent631-643en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Cellular and Molecular Medicineen
dc.relation.ispartofseries13en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectOncologyen
dc.subjectImmunologyen
dc.subjectNF-kappa Ben
dc.subjectNuclear Regulationen
dc.titleNF-κB regulation: The nuclear responseen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/graysten
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanusen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdpen
dc.identifier.rssinternalid59164en


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