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dc.contributor.authorKELLY, DANIELen
dc.date.accessioned2010-10-15T15:05:47Z
dc.date.available2010-10-15T15:05:47Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationDaniel J. Kelly, Christopher R. Jacobs, The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells, Birth Defects Research Part C: Embryo Today: Reviews, 90, 1, 2010, 75-85en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/41078
dc.descriptionPUBLISHEDen
dc.description.abstractIt is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in response to its extracellular environment, and extrinsic mechanical signals imposed upon the cell by the extracellular environment, play a central role in determining MSC fate. This article reviews chondrogenesis and osteogenesis during skeletogenesis, and then considers the role of mechanics in regulating limb development and regenerative events such as fracture repair. However, observing skeletal changes under altered loading conditions can only partially explain the role of mechanics in controlling MSC differentiation. Increasingly, understanding how epigenetic factors, such as the mechanical environment, regulate stem cell fate is undertaken using tightly controlled in vitro models. Factors such as bioengineered surfaces, substrates, and bioreactor systems are used to control the mechanical forces imposed upon, and generated within, MSCs. From these studies, a clearer picture of how osteogenesis and chondrogenesis of MSCs is regulated by mechanical signals is beginning to emerge. Understanding the response of MSCs to such regulatory factors is a key step towards understanding their role in development, disease and regeneration. Birth Defects Research (Part C) 90:75?85, 2010en
dc.description.sponsorshipFulbright Program and Science Foundation Ireland President of Ireland Young Researcher Award. Grant Number: (08/Y15/B1336) National Institute of Health Grants. Grant Numbers: AR45989, AR54156 New York State Stem Cell grant. Grant Number: N089-210en
dc.format.extent75-85en
dc.language.isoenen
dc.relation.ispartofseriesBirth Defects Research Part C: Embryo Today: Reviewsen
dc.relation.ispartofseries90en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectBioengineeringen
dc.subjectmesenchymal stem cellen
dc.subjectosteogenesisen
dc.subjectchondrogenesisen
dc.subjectmechanobiologyen
dc.subjectmechano-transductionen
dc.subjectbioreactoren
dc.titleThe role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cellsen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellyd9en
dc.identifier.rssinternalid68510en
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.identifier.rssurihttp://dx.doi.org/10.1002/bdrc.20173en


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