Browsing Psychiatry by Author "DONOHOE, GARY"
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Age at first birth in women is genetically associated with increased risk of schizophrenia
DONOHOE, GARY; GILL, MICHAEL (2018) -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility
DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL (2014) -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
CORVIN, AIDEN; DONOHOE, GARY (2014)Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
MORRIS, DEREK; BRADLEY, DANIEL; DONOHOE, GARY; GILL, MICHAEL; CORVIN, AIDEN; FAHEY, CIARA; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL (2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
DONOHOE, GARY (2013)Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity ... -
Clinical symptomatology and the psychosis risk gene, ZNF804A
CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL (2010)The single nucleotide polymorphism (SNP) rs1344706, mapping to the gene ZNF804A, has been implicated in schizophrenia susceptibility ([O'Donovan et al., 2008], [International Schizophrenia Consortium, 2009], [Stefansson ... -
Compliance Therapy: A Randomised Controlled Trial In Schizophrenia.
DONOHOE, GARY (2003)OBJECTIVE: To evaluate the efficacy of "compliance therapy" for improving adherence to prescribed drug treatment among patients with schizophrenia. DESIGN: Randomised controlled trial. SETTING: Urban catchment ... -
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
DONOHOE, GARY; GILL, MICHAEL (2018) -
Effect of genetic variant in BICCI on functional and structural brain changes in depression
GILL, MICHAEL; DONOHOE, GARY; FAGAN, ANDREW; MORRIS, DEREK; FRODL, THOMAS (2012) -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
MORRIS, DEREK; DONOHOE, GARY; HARGREAVES, APRIL; GILL, MICHAEL; FAHEY, CIARA; CORVIN, AIDEN; TROPEA, DANIELA (2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
The effects of psychosis risk variants on brain connectivity: a review.
DONOHOE, GARY (2012)n light of observed changes in connectivity in schizophrenia and the highly heritable nature of the disease, neural connectivity may serve as an important intermediate phenotype for schizophrenia. However, how individual ... -
Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.
DONOHOE, GARY (2013)Although the genome wide supported psychosis susceptibility neurogranin (NRGN) gene is expressed in human brains, it is unclear how it impacts brain morphology in schizophrenia. We investigated the influence of NRGN ... -
Effects of ZNF804A on auditory P300 response in schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; TROPEA, DANIELA (2014) -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
MORRIS, DEREK; DONOHOE, GARY (2014) -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
FRODL, THOMAS; DONOHOE, GARY; LOPEZ, LORNA (2014)The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ... -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
CORVIN, AIDEN; DONOHOE, GARY; GILL, MICHAEL (Elsevier (Cell Press), 2018)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ... -
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
CORVIN, AIDEN; HERON, ELIZABETH; GILL, MICHAEL; DONOHOE, GARY; ANNEY, RICHARD; GALLAGHER, LOUISE; MORRIS, DEREK; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
GILL, MICHAEL; DONOHOE, GARY; CORVIN, AIDEN; MORRIS, DEREK; FRODL, THOMAS (2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
GILL, MICHAEL; DONOHOE, GARY; KENNY, ELAINE (2013)Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use ...