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dc.contributor.authorWOLFE, KENNETH
dc.date.accessioned2010-08-18T11:46:34Z
dc.date.available2010-08-18T11:46:34Z
dc.date.issued2006
dc.date.submitted2006en
dc.identifier.citationKosa, P., Valach, M., Tomasaka, L., Wolfe, K. H. & Nosek, J., Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: Insight into the evolution of linear DNA genomes from mitochondrial telomere mutants., Nucleic Acids Research, 34, 8, 2006, 2472-2481en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/40532
dc.descriptionPUBLISHEDen
dc.description.abstractWe determined complete mitochondrial DNA sequences of the two yeast species, Candida orthopsilosis and Candida metapsilosis, and compared them with the linear mitochondrial genome of their close relative, C.parapsilosis. Mitochondria of all the three species harbor compact genomes encoding the same set of genes arranged in the identical order. Differences in the length of these genomes result mainly from the presence/absence of introns. Multiple alterations were identified also in the sequences of the ribosomal and transfer RNAs, and proteins. However, the most striking feature of C.orthopsilosis and C.metapsilosis is the existence of strains differing in the molecular form of the mitochondrial genome (circular-mapping versus linear). Their analysis opens a unique window for understanding the role of mitochondrial telomeres in the stability and evolution of molecular architecture of the genome. Our results indicate that the circular-mapping mitochondrial genome derived from the linear form by intramolecular end-to-end fusions. Moreover, we suggest that the linear mitochondrial genome evolved from a circular-mapping form present in a common ancestor of the three species and, at the same time, the emergence of mitochondrial telomeres enabled the formation of linear monomeric DNA forms. In addition, comparison of isogenic C.metapsilosis strains differing in the form of the organellar genome suggests a possibility that, under some circumstances, the linearity and/or the presence of telomeres provide a competitive advantage over a circular-mapping mitochondrial genome.en
dc.description.sponsorshipThe authors wish to thank L. Kovac (Comenius University, Bratislava) for continuous support and helpful comments, S. A. Meyer (Georgia State University, Atlanta) for discussion, and members of our laboratories for discussions and/or technical assistance. This work was supported by grants from the Howard Hughes Medical Institute (55000327), the Fogarty International Research Collaboration Award (2-R03- TW005654-04A1), the Slovak grant agencies VEGA (1/2331/ 05, 1/0006/03), APVT (20-003902, 20-001604), the Comenius University (UK/181/2005) and Science Foundation Ireland. Funding to pay the Open Access publication charges for this article was provided by the grant from the Howard Hughes Medical Institute (55005622).en
dc.format.extent2472-2481en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartofseriesNucleic Acids Research;
dc.relation.ispartofseries34;
dc.relation.ispartofseries8;
dc.rightsYen
dc.subjectGeneticsen
dc.subjectCandida orthopsilosisen
dc.subjectCandida metapsilosisen
dc.titleComplete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: Insight into the evolution of linear DNA genomes from mitochondrial telomere mutants.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/khwolfe
dc.identifier.rssinternalid44153
dc.identifier.rssurihttp://dx.doi.org/10.1093/nar/gkl327en


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