Show simple item record

dc.contributor.authorCONNON, STEPHENen
dc.contributor.authorGRAYSON, DAVIDen
dc.contributor.authorPOWER, DAVID PATRICKen
dc.date.accessioned2010-08-17T15:47:13Z
dc.date.available2010-08-17T15:47:13Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationDavid P. Power, Olivier Lozach, Laurent Meijer, David H. Grayson, Stephen J. Connon, Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones, Bioorganic & Medicinal Chemistry Letters, 20, 16, 2010, 4940-4944en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/40480
dc.descriptionPUBLISHEDen
dc.description.abstractA remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing 9-azapaullone and its protonated, N-oxidised and N-alkylated derivatives. Screening studies identified an active and strongly selective inhibitor of CDK9/cyclin Ten
dc.format.extent4940-4944en
dc.language.isoenen
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Lettersen
dc.relation.ispartofseries20en
dc.relation.ispartofseries16en
dc.rightsYen
dc.subjectBiochemistryen
dc.subjectCyclin Dependent Kinasesen
dc.titleConcise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullonesen
dc.typeJournal Articleen
dc.contributor.sponsorHigher Education Authority (HEA)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/connonsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dgraysonen
dc.identifier.rssinternalid67227en
dc.subject.TCDThemeCanceren
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.bmcl.2010.06.024en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record