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dc.contributor.authorO'BRIEN, FERGALen
dc.date.accessioned2010-06-29T12:01:40Z
dc.date.available2010-06-29T12:01:40Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationStops AJ, Harrison NM, Haugh MG, O'Brien FJ, McHugh PE, Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis., Journal of the Mechanical Behavior of Biomedical Materials, 3, 4, 2010, 292-302en
dc.identifier.issn1878-0180en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/40218
dc.descriptionPUBLISHEDen
dc.description.abstractArtificial tissue growth requires cells to proliferate and differentiate within the host scaffold. As cell function is governed by mechano-sensitive selection, tissue type is influenced by the microscopic forces exposed to the cells, which is a product of macroscopically straining the scaffold. Accordingly, the microscopic strain environment within a CG scaffold is offered here. Using ?CT to characterise CG scaffold architecture, two high-resolution 3D FE models were used to predict the deformation mechanics. While also providing an analysis of region-specific features, such as relative density, pore diameters and microstructural elastic stability, the deformation patterns afforded strains to be inferred for seeded cells. The results indicate a regional dependence, in terms of architectural and mechanical properties. Specifically, the peripheral regions demonstrated the lowest volume fraction, the highest stress concentrations and the greatest potential for elastic instability. Conversely, the mid-region exhibited the most homogeneous environment. Based on the proviso of mechano-sensitive proliferation and differentiation, the findings suggest cell function will vary between CG scaffold regions. Further work should investigate the possibility of improving the fabrication process in order to deliver a construct in line with the mid-region, or alternatively, isolation of the mid-region may prove beneficial for cell culturing.en
dc.description.sponsorshipFunding for this work was provided by the Programme for Research in Third Level Institutions (PRTLI), administered by the Higher Education Authority (HEA) and a SFI Foundation Ireland President of Ireland Young Researcher Award (O'Brien)en
dc.format.extent292-302en
dc.language.isoenen
dc.relation.ispartofseriesJournal of the Mechanical Behavior of Biomedical Materialsen
dc.relation.ispartofseries3en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectBioengineeringen
dc.subjectcell functionen
dc.subjectcollagen-glycosaminoglycan scaffolden
dc.titleLocal and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fobrienen
dc.identifier.rssinternalid67366en
dc.identifier.doihttp://dx.doi.org/10.1016/j.jmbbm.2009.12.003en
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.jmbbm.2009.12.003en


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