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dc.contributor.authorHOLLAND, CELIA
dc.date.accessioned2010-06-18T16:01:16Z
dc.date.available2010-06-18T16:01:16Z
dc.date.issued1997
dc.date.submitted1997en
dc.identifier.citationCrofton, P.M., Wade, J.C., Taylor, M.R.H. and Holland, C., Serum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren, Clinical Chemistry, 43, 9, 1997, 1577, 1581en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/40196
dc.descriptionPUBLISHEDen
dc.description.abstractWe report pediatric age- and sex-specific 95% reference intervals for procollagen type I C-terminal propeptide (PICP), the cross-linked C-terminal telopeptide of type I collagen (ICTP), and procollagen type III N-terminal propeptide (P3NP), measured in plasma from 302 schoolchildren (156 boys, 146 girls) ages 4-19 years. All three markers displayed a significant variation with age (ANOVA P < or = 0.0015). PICP showed no detectable increase during adolescence for either sex, but decreased towards adult concentrations after the age of puberty, with an earlier decrease for girls than for boys (P < 0.01). ICTP and P3NP both increased in pubertal-aged children (P < 0.05), with an earlier increase in girls than in boys (P < 0.05), before decreasing towards adult concentrations (P < 0.01). All three collagen markers were highly correlated with one another (P < 0.001). The patterns observed mirrored the childhood growth curve and reflected the high turnover of bone and soft tissue during childhood growth.en
dc.format.extent1577en
dc.format.extent1581en
dc.language.isoenen
dc.publisherAmerican Association for Clinical Chemistryen
dc.relation.ispartofseriesClinical Chemistry;
dc.relation.ispartofseries43;
dc.relation.ispartofseries9;
dc.rightsYen
dc.subjectBiochemistryen
dc.subjectPaediatricsen
dc.subjectprocollagenen
dc.titleSerum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildrenen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cholland
dc.identifier.rssinternalid28715


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