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dc.contributor.authorHOLLAND, CELIA
dc.date.accessioned2010-06-18T15:59:51Z
dc.date.available2010-06-18T15:59:51Z
dc.date.issued1999
dc.date.submitted1999en
dc.identifier.citationMcSharry, C., Xia, Y., Holland, C. and Kennedy, M.W., Natural immunity to Ascaris lumbricoides associated with IgE antibody to ABA-1 allergen and inflammatory indicators in children, Infection and Immunity, 67, 1999, 484 - 489en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/40194
dc.descriptionPUBLISHEDen
dc.description.abstractChildren putatively immune to the large roundworm Ascaris lumbricoides were identified in an area of Nigeria where infection is hyperendemic. Immunity was associated with higher levels of serum ferritin, C-reactive protein, and eosinophil cationic protein, indicating ongoing acute phase or inflammatory processes. In contrast, children who were susceptible to the infection had little serological evidence of inflammation despite their high parasite burdens. Immunoglobulin G (IgG) antibody activity in all subclasses was present in high titer in most children but appeared to have no protective function. Despite exceptionally high total IgE levels, there was no evidence that atopic responses to local common allergens was associated with natural immunity to Ascaris. Among those individuals who produced IgG antibody to recombinant ABA-1 allergen of Ascaris, the naturally immune group had significantly more IgE antibody to the allergen than did those susceptible to the infection. IgE antibody responses in conjunction with innate inflammatory processes therefore appear to associate with natural immunity to ascariasis.en
dc.format.extent484en
dc.format.extent489en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofseriesInfection and Immunity;
dc.relation.ispartofseries67;
dc.rightsYen
dc.subjectParasitologyen
dc.subjectAscaris lumbricoidesen
dc.titleNatural immunity to Ascaris lumbricoides associated with IgE antibody to ABA-1 allergen and inflammatory indicators in childrenen
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trusten
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cholland
dc.identifier.rssinternalid28728
dc.identifier.rssurihttp://iai.asm.org/cgi/reprint/67/2/484en


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