Show simple item record

dc.contributor.authorHOLLAND, CELIAen
dc.date.accessioned2010-06-17T14:14:44Z
dc.date.available2010-06-17T14:14:44Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationCelia V. Holland, Predisposition to ascariasis: patterns, mechanisms and implications, Parasitology, Centenary Volume, 136, 2009, 1537 - 1547en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/40174
dc.descriptionPUBLISHEDen
dc.description.abstractAscaris lumbricoides, the human roundworm, is a remarkably infectious and persistent parasite. It is a member of the soil-transmitted helminths or geohelminths and infects in the order of 1472 million people worldwide. Despite, its high prevalence and wide distribution it remains along with its geohelminth counterparts, a neglected disease. Ascariasis is associated with both chronic and acute morbidity, particularly in growing children, and the level of morbidity assessed as disability-adjusted life years is about 10?5 million. Like other macroparasite infections, the frequency distribution of A. lumbricoides is aggregated or overdispersed with most hosts harbouring few or no worms and a small proportion harbouring very heavy infections. Furthermore, after chemotherapeutic treatment, individuals demonstrate consistency in the pattern of re-infection with ascariasis, described as predisposition. These epidemiological phenomena have been identified, in a consistent manner, from a range of geographical locations in both children and adults. However, what has proved to be much more refractory to investigation has been the mechanisms that contribute to the observed epidemiological patterns. Parallel observations utilizing human subjects and appropriate animal model systems are essential to our understanding of the mechanisms underlying susceptibility/resistance to ascariasis. Furthermore, these patterns of Ascaris intensity and re-infection have broader implications with respect to helminth control and interactions with other important bystander infections.en
dc.format.extent1537en
dc.format.extent1547en
dc.language.isoenen
dc.relation.ispartofseriesParasitologyen
dc.relation.ispartofseriesCentenary Volumeen
dc.relation.ispartofseries136en
dc.rightsYen
dc.subjectZoologyen
dc.subjectAscaris lumbricoidesen
dc.subjecthelminthen
dc.titlePredisposition to ascariasis: patterns, mechanisms and implicationsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/chollanden
dc.identifier.rssinternalid55571en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://dx.doi.org/10.1017/S0031182009005952en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record