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dc.contributor.authorWOLFE, KENNETHen
dc.date.accessioned2010-06-16T09:39:40Z
dc.date.available2010-06-16T09:39:40Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationNora Khaldi, Fayaz T. Seifuddin, Geoff Turner, Daniel Haft, William C. Nierman, Kenneth H. Wolfe, Natalie D. Fedorova, SMURF: genomic mapping of fungal secondary metabolite clusters, Fungal Genetics and Biology, 47, 9, 2010, 736-741en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/40152
dc.descriptionPUBLISHEDen
dc.description.abstractFungi produce an impressive array of secondary metabolites (SMs) including mycotoxins, antibiotics and pharmaceuticals. The genes responsible for their biosynthesis, export, and transcriptional regulation are often found in contiguous gene clusters. To facilitate annotation of these clusters in sequenced fungal genomes, we developed the web-based software SMURF (www.jcvi.org/smurf/) to systematically predict clustered SM genes based on their genomic context and domain content. We applied SMURF to catalog putative clusters in 27 publicly available fungal genomes. Comparison with genetically characterized clusters from six fungal species showed that SMURF accurately recovered all clusters and detected additional potential clusters. Subsequent comparative analysis revealed the striking biosynthetic capacity and variability of the fungal SM pathways and the correlation between unicellularity and the absence of SMs. Further genetics studies are needed to experimentally confirm these clusters.en
dc.format.extent736-741en
dc.language.isoenen
dc.relation.ispartofseriesFungal Genetics and Biologyen
dc.relation.ispartofseries47en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectGeneticsen
dc.subjectsecondary metabolitesen
dc.titleSMURF: genomic mapping of fungal secondary metabolite clustersen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/khwolfeen
dc.identifier.rssinternalid67200en
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.fgb.2010.06.003en


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