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dc.contributor.authorPRENDERGAST, PATRICK JOHN
dc.contributor.authorO'BRIEN, FERGAL
dc.date.accessioned2010-05-19T15:22:22Z
dc.date.available2010-05-19T15:22:22Z
dc.date.issued2007
dc.date.submitted2007en
dc.identifier.citationO Brien, F.J.; Harley, B.A.; Waller, M.A.; Yannas, I.V; Gibson, L.J and Prendergast, P.J., The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering., Technology and Healthcare, 15, 1, 2007, 3, 17en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/39607
dc.descriptionPUBLISHEDen
dc.description.abstractThe permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing the pressure fields within the construct. The objective of this study was to characterize the permeability/fluid mobility of collagen-GAG scaffolds as a function of pore size and compressive strain using both experimental and mathematical modeling techniques. Scaffolds containing four distinct mean pore sizes (151, 121, 110, 96 microns) were fabricated using a freeze-drying process. An experimental device was constructed to measure the permeability of the scaffold variants at different levels of compressive strain (0, 14, 29 and 40% while a low-density open-cell foam cellular solids model utilizing a tetrakaidecahedral unit cell was used to accurately model the permeability of each scaffold variant at all level of applied strain. The results of both the experimental and the mathematical analysis revealed that scaffold permeability increases with increasing pore size and decreases with increasing compressive strain. The excellent comparison between experimentally measured and predicted scaffold permeability suggests that cellular solids modelling techniques can be utilized to predict scaffold permeability under a variety of physiological loading conditions as well as to predict the permeability of future scaffolds with a wide variety of pore microstructures.en
dc.format.extent3en
dc.format.extent17en
dc.language.isoenen
dc.publisherIOS Pressen
dc.relation.ispartofseriesTechnology and Healthcare;
dc.relation.ispartofseries15;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectCollagenen
dc.subjecttissue engineeringen
dc.titleThe effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.en
dc.contributor.sponsorHigher Education Authority
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fobrien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pprender
dc.identifier.rssinternalid44077
dc.identifier.rssurihttp://iospress.metapress.com/content/7nfbju6qqhlpwkg2/fulltext.pdfen


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