IL-10 inhibits miR-155 induction by Toll-like receptors.
Item Type:Journal Article
Citation:McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, 27, 2010, 20492-20498
IL-10 inhibits miR-155 induction by Toll-like receptors.pdf (Published (publisher's copy) - Peer Reviewed) 428.2Kb
IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs play a role in the inhibitory effect of IL-10 on TLR4 signalling. Analysing miRNAs known to be induced by TLR4, we found that IL-10 could inhibit the expression of miR-155 in response to LPS, but had no effect on miR-21 or miR-146a. IL-10 inhibited miR-155 transcription from the BIC gene in a STAT3 dependent manner. This inhibitory effect of IL-10 on miR-155 led to an increase in the expression of the miR-155 target gene, SHIP1. This is the first example of IL-10 playing a role in miRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression.
Health Research Board (HRB)
European Union (EU)
Science Foundation Ireland (SFI)
Author: O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK
Type of material:Journal Article
Series/Report no:The Journal of Biological Chemistry
Availability:Full text available
Keywords:anti-inflammatory gene expression