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dc.contributor.authorO'DRISCOLL, LORRAINEen
dc.date.accessioned2010-04-30T14:40:31Z
dc.date.available2010-04-30T14:40:31Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationHennessy E, Clynes M, Jeppesen P, O'Driscoll L, Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells., Biochemical and Biophysical Research Communications, 396, 2, 2010, 457 - 462en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/39365
dc.descriptionPUBLISHEDen
dc.description.abstractMicroRNAs (miRNAs) are a family of endogenous small non-coding RNAs which regulate mRNAs at the post-transcriptional level. MiRNAs have been identified in both normal physiological and pathological conditions. To date, a limited number of miRNAs have been shown to be involved in the regulation of insulin secretion. We have identified a panel of 10 miRNAs down-regulated in glucose non-responsive MIN6 cells compared to glucose responsive cells using TaqMan Low Density human microRNA arrays. Of these 10 miRNA targets, subsequent functional investigations involving knockdown of mir-200a, mir-130a and mir-410 levels suggested that they may decrease the capability of MIN6 cells to secrete insulin in response to stimulatory levels of glucose. Conversely, experiment with over-expression of mir-410 suggest that it may enhance levels of glucose stimulated insulin secretion. In this study, we have also identified 21 miRNAs not previously known to have a potential murine homolog.en
dc.format.extent457en
dc.format.extent462en
dc.language.isoenen
dc.relation.ispartofseriesBiochemical and Biophysical Research Communicationsen
dc.relation.ispartofseries396en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectmicroRNAen
dc.subjectGSISen
dc.subjectinsulin secretionen
dc.subjectMIN6en
dc.titleIdentification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells.en
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lodriscen
dc.identifier.rssinternalid66149en
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbrc.2010.04.116en
dc.subject.TCDThemeGenes & Societyen
dc.identifier.rssurihttp://hdl.handle.net/2262/39365en
dc.identifier.orcid_id0000-0002-9860-8262en


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