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dc.contributor.authorGILL, MICHAELen
dc.date.accessioned2010-04-07T13:36:17Z
dc.date.available2010-04-07T13:36:17Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationJ. Park, M. Willmott, G. Vetuz, C. Toye, A. Kirley, Z. Hawi, K.J. Brookes, M. Gill, L. Kent, Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 4, 2010, 697-702en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/38876
dc.descriptionPUBLISHEDen
dc.descriptionpmid 20347913en
dc.description.abstractSome children with ADHD also have social and communication difficulties similar to those seen in children with autistic spectrum disorders and this may be due to shared genetic liability. As the oxytocin receptor (OXTR) gene has been implicated in social cognition and autistic spectrum disorders, this study investigated whether OXTR polymorphisms previously implicated in autism were associated with ADHD and whether they influenced OXTR mRNA expression in 27 normal human amygdala brain samples. The family based association sample consisted of 450 DSM-IV diagnosed ADHD probands and their parents. Although there was no association with the ADHD phenotype, an association with social cognitive impairments in a subset of the ADHD probands (N = 112) was found for SNP rs53576 (F = 5.24, p = 0.007) with post hoc tests demonstrating that the AA genotype was associated with better social ability compared to the AG genotype. Additionally, significant association was also found for rs13316193 (F = 3.09, p = 0.05) with post hoc tests demonstrating that the CC genotype was significantly associated with poorer social ability than the TT genotype. No significant association between genotype and OXTR mRNA expression was found. This study supports previous evidence that the OXTR gene is implicated in social cognition.en
dc.format.extent697-702en
dc.language.isoenen
dc.relation.ispartofseriesProgress in Neuro-Psychopharmacology and Biological Psychiatryen
dc.relation.ispartofseries34en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectADHDen
dc.subjectOXTRen
dc.subjectAssociationen
dc.subjectSocial Cognitionen
dc.subjectHuman post mortem brain tissueen
dc.titleEvidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHDen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid65196en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.pnpbp.2010.03.029en


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