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dc.contributor.authorCORVIN, AIDEN PETER
dc.contributor.authorGILL, MICHAEL
dc.contributor.authorSEGURADO, RICARDO
dc.date.accessioned2010-01-26T16:52:54Z
dc.date.available2010-01-26T16:52:54Z
dc.date.issued2002
dc.date.submitted2002en
dc.identifier.citationP. Bennett, R. Segurado, I. Jones, S. Bort, F. McCandless, D. Lambert, J. Heron, C. Comerford, F. Middle, A. Corvin, G. Pelios, G. Kirov, B. Larsen, T. Mulcahy, N. Williams, R. O'Connell, E. O'Mahony, A. Payne, M. Owen, P. Holmans, N. Craddock and M. Gill, The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report, Molecular Psychiatry, 7, 2, 2002, 189-200en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/36371
dc.descriptionPUBLISHEDen
dc.description.abstractWe have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included 509 subjects from 151 nuclear families recruited within the United Kingdom and Republic of Ireland. This sample contained 154 narrowly defined affected sibling pairs (DSM-IV BPI) and 258 broadly defined affected sibling pairs (DSM-IV BPI, SABP, BPII, BPNOS or MDD(R)), approximately two thirds of all families contained at least one other additional typed individual. All individuals were genotyped using 398 highly polymorphic microsatellite markers from Applied Biosystems's Linkage Mapping Set Version 2. The average inter-marker distance was 9.6 cM and the mean heterozygosity was 0.78. Analysis of these data using non-parametric linkage methods (MAPMAKER/SIBS) found no evidence for loci of major effect and no regions reached genome-wide significance for either suggestive or significant linkage. We identified 19 points across the genome where the MLS exceeded a value set for follow up in our second stage screen (MLS0.74 (equivalent to a nominal pointwise significance of 5%) under the narrowest diagnostic model). These points were on chromosomes 2, 3, 4, 6, 7, 9, 10, 12, 17, 18 & X. Some of these points overlapped with previous linkage reports both within bipolar affective disorder and other psychiatric illnesses. Under the narrowest diagnostic model, the single most significant multipoint linkage was on chromosome 18 at marker D18S452 (MLS=1.54). Overall the highest MLS was 1.70 on chromosome 2 at marker D2S125, under the broadest diagnostic model.en
dc.description.sponsorshipWellcome Trusten
dc.format.extent189-200en
dc.format.extent768736 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofseriesMolecular Psychiatryen
dc.relation.ispartofseries7en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectGeneticsen
dc.subjectLinkageen
dc.subjectlod scoreen
dc.subjectmanic-depressiveen
dc.subjectmicrosatellite repeatsen
dc.titleThe Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage reporten
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trusten
dc.contributor.sponsorWellcome Trust
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/acorvin
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgill
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rsegurdo
dc.identifier.rssinternalid21132
dc.identifier.rssurihttp://dx.doi.org/10.1038/sj/mp/4000957


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