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dc.contributor.authorGILL, MICHAELen
dc.contributor.authorHAWI, ZIARIHen
dc.date.accessioned2010-01-26T16:52:06Z
dc.date.available2010-01-26T16:52:06Z
dc.date.issued2002en
dc.date.submitted2002en
dc.identifier.citationKent L, Doerry U, Hardy E, Parmar R, Gingell K, Hawi Z, Kirley A, Lowe N, Fitzgerald M, Gill M, Craddock N., Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis., Molecular Psychiatry, 7, 2002, 908, 912en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/36370
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 12232786en
dc.description.abstractReduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.1,2 Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD.3,4 Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, chi2 = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (chi2 = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3' UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3' UTR SNP (chi2 = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3' UTR SNP with the long allele of the promoter polymorphism (chi2 = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (chi2 = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.en
dc.description.sponsorshipHealth Research Board Wellcome Trusten
dc.format.extent908en
dc.format.extent912en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesMolecular Psychiatryen
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectADHDen
dc.subject5HTTen
dc.subjecthSERTen
dc.subjectassociation studyen
dc.titleEvidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.en
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zhhawien
dc.identifier.rssinternalid33708en
dc.identifier.doihttp://dx.doi.org/10.1038/sj.mp.4001100en
dc.identifier.rssurihttp://dx.doi.org/10.1038/sj.mp.4001100


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