Immune modulation: IL-1, master mediator or initiator of inflammation
Citation:Mills KH, Dunne A, Immune modulation: IL-1, master mediator or initiator of inflammation, Nature Medicine, 15, 12, 2009, 1363-1364
IL-1 ? Master mediator or initiator of inflammation.pdf (Published (author's copy) - Peer Reviewed) 239.6Kb
Interleukin-1 (IL-1) lies at the center of the inflammatory response. This proinflammatory cytokine was first pinned down for its ability to induce fever, and was later assigned additional biological functions including neutrophil recruitment, lymphocyte activation and induction of inflammatory mediators1. Excessive production of IL-1? drives the recurrent episodes of fever and systemic inflammation in certain autoinflammatory diseases, linked to mutations in genes regulating innate immunity; such conditions include familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS)2, as well as gout, a condition where IL-1? induced by monosodium urate crystals (MSU) causes inflammatory response in joints.
Type of material:Review
Series/Report no:Nature Medicine
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection