Browsing Pharmacology & Therapeutics by Subject "Blood-brain barrier"
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Association of PP2A and VE-cadherin in a mono and co-culture with implications on brain microvascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Introduction: Based on the knowledge that VE-cadherin is an integral component of the functioning endothelium in the blood brain barrier. Its transcellular abundance can be altered by post-translational modifications and ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ...