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dc.contributor.authorMCLOUGHLIN, DECLAN
dc.date.accessioned2009-11-13T15:09:43Z
dc.date.available2009-11-13T15:09:43Z
dc.date.issued2007
dc.date.submitted2007en
dc.identifier.citationEranti S, Mogg A, Pluck G, Landau S, Purvis R, Brown RG, Howard R, Knapp M, Philpot M, Rabe-Hesketh S, Romeo R, Rothwell J, Edwards D, McLoughlin DM `A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression? in American Journal of Psychiatry, 164, 2007, pp 73-81en
dc.identifier.otherY
dc.identifier.other61469
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34709
dc.descriptionPUBLISHEDen
dc.description.abstractOBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial to test the equivalence of rTMS with ECT. METHOD: Forty-six patients with major depression referred for ECT were randomly assigned to either a 15-day course of rTMS of the left dorsolateral prefrontal cortex (N=24) or a standard course of ECT (N=22). The primary outcome measures were the score on the 17-item Hamilton Depression Rating Scale (HAM-D) and the proportion of patients with remissions (Hamilton score, 8) at the end of treatment. Secondary outcomes included mood self-ratings on the Beck Depression Inventory-II and visual analogue mood scales, Brief Psychiatric Rating Scale (BPRS) score, and both self-reported and observer-rated cognitive changes. The patients were followed up after 6 months. RESULTS: HAM-D scores at the end of treatment were significantly lower for ECT, with 13 patients (59.1%) achieving remission in the ECT group and four (16.7%) in the rTMS group. However, at 6 months the HAM-D scores did not differ between groups. Beck scale, visual analogue mood scale, and BPRS scores were lower for ECT at the end of treatment and remained lower after 6 months. Self- and observer-rated cognitive measures were similar in the two groups. CONCLUSIONS: rTMS was not as effective as ECT, and ECT was substantially more effective for the short-term treatment of depression.en
dc.format.extent73-81en
dc.format.extent174563 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherAmerican Psychiatric Associationen
dc.relation.ispartofseriesAmerican Journal of Psychiatryen
dc.relation.ispartofseries164en
dc.rightsYen
dc.subjectPsychiatryen
dc.titleA Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depressionen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclougde
dc.identifier.rssurihttp://dx.doi.org/10.1176/appi.ajp.164.1.73


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