Show simple item record

dc.contributor.authorMOLLOY, ANNE MARIE
dc.contributor.authorSCOTT, JOHN MARTIN
dc.date.accessioned2009-11-05T09:30:11Z
dc.date.available2009-11-05T09:30:11Z
dc.date.issued2009
dc.date.submitted2009en
dc.identifier.citationMolloy, A.M., Kirke, P.N., Troendle, J.F., Burke, H., Sutton, M., Brody, L.C., Scott, J.M., Mills, J.L., `Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification? in Pediatrics, 123, (3), 2009, pp 917 - 923en
dc.identifier.issnhttp://dx.doi.org/10.1542/peds.2008-1173
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other59366
dc.identifier.urihttp://hdl.handle.net/2262/34511
dc.descriptionPUBLISHEDen
dc.description.abstractOBJECTIVE. Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is important to identify other modifiable risk factors. Vitamin B12 is metabolically related to folate; moreover, previous studies have found low B12 status in mothers of children affected by neural tube defect. Our objective was to quantify the effect of low B12 status on neural tube defect risk in a high-prevalence, unfortified population. METHODS. We assessed pregnancy vitamin B12 status concentrations in blood samples taken at an average of 15 weeks? gestation from 3 independent nested case-control groups of Irish women within population-based cohorts, at a time when vitamin supplementation or food fortification was rare. Group 1 blood samples were from 95 women during a neural tube defect?affected pregnancy and 265 control subjects. Group 2 included blood samples from 107 women who had a previous neural tube defect birth but whose current pregnancy was not affected and 414 control subjects. Group 3 samples were from 76 women during an affected pregnancy and 222 control subjects. RESULTS. Mothers of children affected by neural tube defect had significantly lower B12 status. In all 3 groups those in the lowest B12 quartiles, compared with the highest, had between two and threefold higher adjusted odds ratios for being the mother of a child affected by neural tube defect. Pregnancy blood B12 concentrations of <250 ng/L were associated with the highest risks. CONCLUSIONS. Deficient or inadequate maternal vitamin B12 status is associated with a significantly increased risk for neural tube defects. We suggest that women have vitamin B12 levels of >300 ng/L (221 pmol/L) before becoming pregnant. Improving B12 status beyond this level may afford a further reduction in risk, but this is uncertain.en
dc.format.extent306940 bytes
dc.format.extent917en
dc.format.extent923en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherAmerican Academy of Pediatricsen
dc.relation.ispartofseriesPediatricsen
dc.relation.ispartofseries123en
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectvitamin B12 ? cobalamin ? neural tube defects ? folic acid fortification ? folateen
dc.titleMaternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortificationen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jscott


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record