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dc.contributor.authorSCOTT, JOHN MARTIN
dc.date.accessioned2009-11-05T09:26:54Z
dc.date.available2009-11-05T09:26:54Z
dc.date.issued2009
dc.date.submitted2009en
dc.identifier.citationHammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS `Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1? in Clinical Immunology, 133, (1), 2009, pp 132-137en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other62100
dc.identifier.urihttp://hdl.handle.net/2262/34508
dc.descriptionPUBLISHEDen
dc.description.abstractMonocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate status, is a known risk factor for many pathologies with inflammatory etiologies. The present study was undertaken to examine whether there are associations between MCP-1 concentrations and folate/Hcy phenotype or methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype in healthy young adults. In females, MCP-1 concentrations were positively correlated with Hcy and negatively correlated with both serum and red blood cell folate; female smokers and MTHFR 677T carriers had particularly elevated MCP-1 concentrations. Similar relationships were not seen in males. These findings may have implications for understanding the female predominance observed for a range of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.en
dc.description.sponsorshipThis work was supported by the National Institutes of Health (NIH), Grant numbers: R01AR47663, P20RR020741, ES0P3013508, and R01HD039195; the Pennsylvania Department of Health, Grant number: 4100038714; and the British Heart Foundation.en
dc.format.extent166556 bytes
dc.format.extent132-137en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesClinical Immunologyen
dc.relation.ispartofseries133en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectImmunologyen
dc.titleFolate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.en
dc.typeJournal Articleen
dc.contributor.sponsorBritish Heart Foundation (BHF)
dc.contributor.sponsorNational Institutes of Health (NIH)
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jscott
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.clim.2009.06.008


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