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dc.contributor.authorMOLLOY, ANNE MARIEen
dc.date.accessioned2009-11-04T09:29:22Z
dc.date.available2009-11-04T09:29:22Z
dc.date.issued2007en
dc.date.submitted2007en
dc.identifier.citationM.M. Murphy, A.M. Molloy, P.M. Ueland, J.D. Fernandez-Ballart, J. Schneede, V. Arija, J.M. Scott. , Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring., Journal of Nutrition, 137, 8, 2007, 1863 - 1867en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34491
dc.descriptionPUBLISHEDen
dc.descriptionPubMed ID: 17634256en
dc.description.abstractCompromised cobalamin status during pregnancy may put both mother and child at risk of deficiency during lactation and subsequent development. We investigated whether changes in cobalamin status during pregnancy are associated with impaired status in the mother and the cord. Plasma cobalamin, methylmalonic acid (MMA), and holotranscobalamin (holoTC) concentrations were determined in 92 women at preconception, 8, 20, and 32 wk of pregnancy, at labor, and in the cord. All variables [geometric mean percentiles 10, 90 (P10, P90)] were significantly reduced from preconception [cobalamin: 293 (155, 535) pmol/L; holoTC: 63 (38,98) pmol/L; MMA: 0.12 (0.09, 0.17) ?mol/L] by 20 wk of pregnancy [cobalamin: 230 (123, 432) pmol/L; holoTC: 48 (34,78) pmol/L; MMA: 0.11 (0.08, 0.15) ?mol/L P < 0.001]. Plasma cobalamin and holoTC remained lower throughout the remainder of pregnancy [32 wk: 198 (107, 339); labor: 224 (117, 444); P < 0.001] and [32 wk: 45 (26,82); labor: 40 (23,79); P < 0.05], respectively. By 32 wk, MMA was greater than preconception [0.14 (0.09, 0.20) ?mol/L; P < 0.01]. Plasma holoTC at 32 wk and at labor was negatively correlated with cord MMA (r = ?0.51, P < 0.001 and r = ?0.40, P < 0.01, respectively). Women with lower holoTC at preconception had greater increases in MMA at 32 wk and at labor. Maternal MMA at 32 wk and at labor was significantly and independently associated with cord MMA only in women with lower holoTC at preconception (regression models: R2 = 0.707, 0.682, respectively; P < 0.01). The moderate increases observed in the cobalamin biomarker, MMA, during pregnancy may indicate a functional depletion in intracellular cobalamin status.en
dc.format.extent1863en
dc.format.extent1867en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesJournal of Nutritionen
dc.relation.ispartofseries137en
dc.relation.ispartofseries8en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleLongitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/amolloyen
dc.identifier.rssinternalid50219en


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