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dc.contributor.authorMOLLOY, ANNE MARIEen
dc.contributor.authorSCOTT, JOHN MARTINen
dc.date.accessioned2009-11-04T09:28:22Z
dc.date.available2009-11-04T09:28:22Z
dc.date.issued2008en
dc.date.submitted2008en
dc.identifier.citationJ.M. Wallace, M.P. Bonham, J. Strain, E.M. Duffy, P.J. Robson, M. Ward, H. McNulty, P.W.Davidson, G.J. Myers, C.F. Shamlaye, T.W. Clarkson, A.M. Molloy, J.M. Scott, P.M. Ueland., Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study., American Journal of Clinical Nutrition, 87, 2, 2008, 391 - 397en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34489
dc.descriptionPUBLISHEDen
dc.descriptionPubMed ID: 18258630en
dc.description.abstractBACKGROUND: Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns. OBJECTIVE: We investigated the predictors of tHcy in pregnant women recruited in the Seychelles, a population where access to fortified foods is limited and where women habitually consume diets rich in fish, eggs, rice, and fruit. DESIGN: Pregnant women (n = 226) provided blood samples at enrollment, at week 28 of gestation, and at delivery. Cord blood was obtained from a subset of participants (n = 135). RESULTS: As in other studies, maternal tHcy was lower during pregnancy than at delivery, whereas folate and vitamin B-12 status declined significantly to delivery. Despite low maternal folate status at delivery (median: 9.0 nmol/L), with 35% of women in the deficient range (serum folate: <6.8 nmol/L), cord blood folate status (median: 40.2 nmol/L) was similar to concentrations reported in Western populations. Folate was a significant predictor of tHcy at all time points (P < 0.001). In contrast with previous studies, betaine was only a significant predictor of maternal tHcy (P < 0.001) when the essential amino acid methionine was low. CONCLUSIONS: The current study reports 2 important findings. First, fetal requirements for folate are paramount, such that cord blood folate status is maintained, even when maternal status is low. Second, betaine is a significant predictor of tHcy in pregnant women with low serum folate and low serum methionine concentrations.en
dc.description.sponsorshipSupported by grants 5-R01-ES010219 and 2-T32-ES007271 from the US National Institute of Environmental Health Sciences, National Institutes of Health, and by the Government of Seychelles.en
dc.format.extent391en
dc.format.extent397en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesAmerican Journal of Clinical Nutritionen
dc.relation.ispartofseries87en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleHomocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/amolloyen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jscotten
dc.identifier.rssinternalid50224en


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