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dc.contributor.authorFARRAR, JANE
dc.contributor.authorHUMPHRIES, PETER
dc.date.accessioned2009-11-02T17:21:25Z
dc.date.available2009-11-02T17:21:25Z
dc.date.issued2002
dc.date.submitted2002en
dc.identifier.citationFarrar GJ, Kenna PF, Humphries P. `On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention?, Kenna, P. F., EMBO Journal, 21, 2002en
dc.identifier.otherY
dc.identifier.other4722
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/34480
dc.descriptionPUBLISHEDen
dc.description.abstractRetinitis pigmentosa (RP), the group of hereditary conditions involving death of retinal photoreceptors, represents the most prevalent cause of visual handicap among working populations in developed countries. Here we provide an overview of the molecular pathologies associated with such disorders, from which it becomes clearly apparent that RP is one of the most genetically heterogeneous of hereditary conditions for which molecular pathologies have so far been elucidated. While heterogeneity of such magnitude would appear to represent a major impediment to the development of therapeutics, mutation-independent approaches to therapy are being developed to effectively by-pass such diversity in genetic aetiology. The implications of such technologies in terms of therapeutic intervention in RP, and indeed other genetically heterogeneous conditions, will be addressed.en
dc.format.extent253468 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.ispartofseriesEMBO Journalen
dc.relation.ispartofseries21en
dc.rightsYen
dc.subjectMolecular biology
dc.titleOn the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic interventionen
dc.typeReviewen
dc.contributor.sponsorHealth Research Board
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/phumphrs


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