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dc.contributor.authorHUMPHRIES, PETER
dc.date.accessioned2009-11-02T17:15:36Z
dc.date.available2009-11-02T17:15:36Z
dc.date.issued2006
dc.date.submitted2006en
dc.identifier.citationHaverkamp S, Michalakis S, Claes E, Seeliger MW, Humphries P, Biel M and Feigenspan A. `Synaptic plasticity in GNGA3-/- mice: Cone bipolar cells react up0onthe missing cone input and form ectopic synapses with rods? in Journal of Neuroscience, 26, (19), 2006, pp 5248 - 5255en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other44471
dc.identifier.urihttp://hdl.handle.net/2262/34470
dc.descriptionPUBLISHEDen
dc.description.abstractIn the mammalian retina, rods and cones connect to distinct sets of bipolar cells. Rods are presynaptic to a single type of rod bipolar cell, whereas cones connect to different types of cone bipolar cells. Synaptic rewiring between cone photoreceptor terminals and rod bipolar cell dendrites has been described as a general result of photoreceptor degeneration. To investigate whether cone bipolar cells also show synaptic plasticity in the absence of cone input, we studied the connectivity of cone bipolar cell dendrites in CNGA3?/? mice, a model with specific loss of cone photoreceptor function. Dendritic connections of ON and OFF cone bipolar cells were visualized using specific cell markers or by intracellular injection with fluorescent dyes. The results show that cone bipolar cells in CNGA3?/? mice form ectopic synapses with rods. In contrast, cone bipolar cells do not form ectopic synapses with rods in CNGA3?/?Rho?/? mice, in which both types of photoreceptors are nonfunctional. In analogy with these results, we found that input-deprived rod bipolar cells form ectopic synapses with functional cones in Rho?/? mice but not with inoperable cones in the CNGA3?/?Rho?/? mouse. Our data indicate that the formation of ectopic bipolar cell synapses in the outer plexiform layer requires a functional presynaptic photoreceptor.en
dc.description.sponsorshipThis work was supported by Deutsche Forschungsgemeinschaft Grants SFB269/B4, Se837/4-1, and Se837/5-1.en
dc.format.extent1576668 bytes
dc.format.extent5248en
dc.format.extent5255en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherThe Society for Neuroscienceen
dc.relation.ispartofseriesJournal of Neuroscienceen
dc.relation.ispartofseries26en
dc.relation.ispartofseries19en
dc.rightsYen
dc.subjectretina; cones; rods; bipolar cells; dendritic plasticity; ectopic synaptogenesisen
dc.titleSynaptic plasticity in GNGA3-/- mice: Cone bipolar cells react up0onthe missing cone input and form ectopic synapses with rodsen
dc.typeJournal Articleen
dc.contributor.sponsorDeutsche Forschungsgemeinschaft (DFG)
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/phumphrs
dc.identifier.rssurihttp://dx.doi.org/10.1523/JNEUROSCI.4483-05.2006


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