Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram.
Citation:Reynolds, AL, Danciger, M, Farrar, GJ, Humphries, P, Kenna, PF `Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram? in Investigative Ophthalmology & Visual Science, 49, (9), 2008
Influence of a Quantitative Trait Locus on Mouse Chromosome 19 to the Light-Adapted Electroretinogram.pdf (published (publisher copy) peer-reviewed) 180.2Kb
PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake a quantitative genetics study to localize the gene or genes involved. METHODS. Implicit time and amplitude of the a- and b-waves of the single-flash and flicker cone-mediated ERG were recorded as the quantitative traits in reciprocal backcrossed populations. A genome-wide scan was performed with 106 polymorphic markers. Map Manager (release QTXb20) was used to analyze the data and make phenotype?genotype correlations. RESULTS. A quantitative trait locus (QTL) of major effect in controlling variation in both implicit time and amplitude of the cone-mediated ERG localized to the middle of chromosome 19. CONCLUSIONS. Mapping of a QTL influencing both implicit time and b-wave amplitude of the light-adapted ERG represents an initial step toward identifying the gene(s) responsible for this phenotypic variation.
Health Research Board
Science Foundation Ireland
European Union (EU)
Publisher:Association for Research in Vision and Ophthalmology
Type of material:Journal Article
Series/Report no:Investigative Ophthalmology & Visual Science
Availability:Full text available