Show simple item record

dc.contributor.authorKELLEHER, DERMOT P
dc.date.accessioned2009-10-23T18:03:10Z
dc.date.available2009-10-23T18:03:10Z
dc.date.issued1994
dc.date.submitted1994en
dc.identifier.citationX. J. Fan, A. Chua, C. N. Shahi, J. McDevitt, P. W. Keeling and D. Kelleher `Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation? in Gut, 35, (10), 1994, pp 1379-1384en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other21334
dc.identifier.urihttp://hdl.handle.net/2262/34212
dc.descriptionPUBLISHEDen
dc.description.abstractHelicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with H pylori colonisation. Sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were H pylori positive and 30 H pylori negative as assessed by culture, histology, and rapid urease test. H pylori antigen was capable of stimulating peripheral blood lymphocyte proliferative responses even in H pylori negative patients. Peripheral blood lymphocyte proliferative responses to H pylori (but not to purified protein derivative or phythaemagglutinin) were significantly lower in H pylori positive than H pylori negative patients. Similarly, antigen specific proliferative responses and interferon gamma production by gastric lamina propria lymphocytes were also depressed in H pylori positive patients compared with H pylori negative patients. CD8 and CD22 positive lamina propria lymphocytes were increased in H pylori positive patients. These data show that antigen specific responses to H pylori are significantly lower in H pylori positive patients and could indicate activation of antigen specific suppression.en
dc.format.extent1379-1384en
dc.format.extent1316398 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherBMJen
dc.relation.ispartofseriesGuten
dc.relation.ispartofseries35en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleGastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisationen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdp
dc.identifier.rssurihttp://dx.doi.org/10.1136/gut.35.10.1379


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record