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dc.contributor.authorKELLEHER, DERMOT P
dc.date.accessioned2009-10-23T16:23:13Z
dc.date.available2009-10-23T16:23:13Z
dc.date.issued1996
dc.date.submitted1996en
dc.identifier.citationX. Fan, A. Long, M. Goggins, P. W. Keeling and D. Kelleher `Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation? in Gut, 38, (4), 1996, pp 507-512en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other21327
dc.identifier.urihttp://hdl.handle.net/2262/34193
dc.descriptionPUBLISHEDen
dc.description.abstractBACKGROUND--Studies have suggested that expression of the adhesion molecule CD44 may be of prognostic importance in gastric cancer. In addition, there is strong evidence that Helicobacter pylori has a role in gastric cancer. AIMS--To determine the expression of CD44 and its variants (v6, v9) and HLA class II molecules on human gastric epithelial cell and intraepithelial lymphocytes in patients with and without H pylori infection. PATIENTS--Eighteen patients (seven men and 11 women) attending for endoscopic evaluation because of upper gastrointestinal symptoms were included. An additional 10 patients (five men and five women) were analysed for CD44 variant expression). METHODS--Biopsy specimens were taken from the gastric antrum during endoscopy. Gastric epithelial cells and intraepithelial lymphocytes were examined by two colour flow cytometry and compared in patients with and without H pylori infection. RESULTS--Expression of CD44 and its variants (CD44 v9) was increased in epithelial cells but not in intraepithelial lymphocytes. Both epithelial cells and intraepithelial lymphocytes expressed higher levels of HLA class II molecules (DR and DP), possibly as a result of local cytokine production. Furthermore, results showed upregulation of CD44 on a gastric epithelial cell line (AGS) by cytokines and peripheral blood mononuclear cell supernatant. CONCLUSIONS--These data suggest that H pylori, either directly or through a local inflammatory response, is responsible for increased expression of CD44 and its variant CD44 v9. These data are of potential importance in relation to increased expression of CD44 and CD44 v9 on gastric carcinoma.en
dc.description.sponsorshipDK is a Wellcome Senior Fellow in Clinical Science. Aideen Long was supported by the Cancer Research Advancement Board of the Irish Cancer Society.en
dc.format.extent507-512en
dc.format.extent1204044 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherBMJen
dc.relation.ispartofseriesGuten
dc.relation.ispartofseries38en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectClinical Medicineen
dc.titleExpression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisationen
dc.typeJournal Articleen
dc.contributor.sponsorIrish Cancer Society
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdp


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