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dc.contributor.authorKELLEHER, DERMOT P
dc.contributor.authorMCMANUS, ROSS
dc.date.accessioned2009-10-07T18:48:27Z
dc.date.available2009-10-07T18:48:27Z
dc.date.issued2001
dc.date.submitted2001en
dc.identifier.citationB. M. Ryan, R. McManus, J. S. Daly, E. Carton, P. W. Keeling, J. V. Reynolds and D. Kelleher `A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma? in British Journal of Cancer, 85, (10), 2001, pp 1499-1503en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.other21549
dc.identifier.urihttp://hdl.handle.net/2262/33836
dc.descriptionPUBLISHEDen
dc.description.abstractThe incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares some p53-like activity, but in addition, may also play a role in gastrointestinal epithelial inflammatory responses. A non-coding p73 polymorphism (denoted AT or GC) may be functionally significant. We investigated whether this polymorphism might play a role in the aetiopathogenesis of oesophageal cancer. This was a case?control, retrospective study. 84 cases of oesophageal cancer (25 squamous and 59 adenocarcinoma) and 152 normal population controls were genotyped for this polymorphism. Informative cases were examined for p73 LOH within the tumour. AT/AT homozygotes were significantly less prevalent in the oesophageal cancer population (1/84 = 1.2%) compared to controls (15/152 = 9.9%) (P < 0.02), corresponding to an odds ratio of 0.11 (95% C.I. 0.02?0.6, P < 0.02), or 9-fold reduced risk. Moreover, AT/AT homozygotes were significantly less frequent in the cancer population than would be expected under the Hardy?Weinberg hypothesis (P = 0.0099). LOH at the p73 locus was observed in 37.8% (14/37) of the AT/GC heterozygotes studied; in all cases there was loss of the AT allele. Our findings indicate that p73 AT/AT homozygotes appear to be protected against the development of oesophageal cancer. Clinically, this observation could have implications in aiding identification of high-risk Barrett's oesophagus patients.en
dc.description.sponsorshipBM Ryan is supported by PPP Healthcare Medical Trust, UK. R McManus is a Wellcome Lecturer. JS Daly is supported by a grant from the Irish Health Research Boarden
dc.format.extent1499-1503en
dc.format.extent67442 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherNatureen
dc.relation.ispartofseriesBritish Journal of Canceren
dc.relation.ispartofseries85en
dc.relation.ispartofseries10en
dc.rightsYen
dc.subjectoesophageal cancer, p53, p73, polymorphism, genetics, risken
dc.titleA common p73 polymorphism is associated with a reduced incidence of oesophageal carcinomaen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanus
dc.identifier.rssinternalid21369
dc.identifier.rssurihttp://dx.doi.org/10.1054/bjoc.2001.2066


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