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dc.contributor.authorO'NEILL, LUKE ANTHONY JOHN
dc.date.accessioned2009-10-01T17:49:20Z
dc.date.available2009-10-01T17:49:20Z
dc.date.issued1998
dc.date.submitted1998en
dc.identifier.citationO'Neill LA, Greene C. `Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants? in Journal of Leukocyte Biology, 63, (6), 1998, pp 650 - 657en
dc.identifier.otherY
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/33709
dc.descriptionPUBLISHEDen
dc.description.abstractInterleukin-1 (IL-1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been made in the area of IL-1 receptors and IL-1 signal transduction. A family of proteins has been described that share significant homology in their signaling domains with the Type I IL-1 receptor (IL-1RI). These include the IL-1 receptor accessory protein (IL-1AcP), which does not bind IL-1 but is essential for IL-1 signaling; a Drosophila protein Toll; a number of human Toll-like receptors (hTLRs); the putative IL-18/IL-1-gamma receptor IL-1Rrp (IL-1 receptor-related protein); and a number of plant proteins. All appear to be involved in host responses to injury and infection. These homologies also extend to novel signaling proteins implicated in IL-1 action. Two IL-1 receptor-associated kinases, IRAK-1 and IRAK-2, which have homologs in Drosophila (Pelle) and plants (Pto), have been implicated in the activation of the transcription factor, nuclear factor kappaB (NF-kappaB). IRAK-1 has also been implicated in AP1 induction, Jun amino-terminal kinase (JNK) activation, and IL-2 induction. It recruits the adapter protein TRAF6 to the IL-1 receptor complex via an interaction with IL-1AcP. TRAF6 then relays the signal via NF-kappaB-inducing kinase (NIK) to two I-kappaB kinases (IKK-1 and -2), leading to NF-kappaB activation. Progress has also been made on other IL-1-responsive kinases, including JNK and p38 MAP kinase, with the latter having a role in multiple responses to IL-1. The remarkable conservation between diverse species indicates that the IL-1 system represents an ancient signaling machine critical for responses to environmental stresses and attack by pathogens.en
dc.description.sponsorshipThis work was supported by grants from the Irish Health Research Board, the Irish Science and Technology Agency, Forbairt, the Arthritis Foundation of Ireland, and the European Union (EU) BIOMED and BIOTECH programmes.en
dc.format.extent650en
dc.format.extent657en
dc.format.extent678306 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherSociety of Leukocyte Biologyen
dc.relation.ispartofseriesJournal of Leukocyte Biologyen
dc.relation.ispartofseries63en
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjectBiochemistryen
dc.titleSignal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.en
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board
dc.contributor.sponsorEuropean Union (EU)
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneill
dc.identifier.rssinternalid5037


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