dc.contributor.author | Lynch, Marina | en |
dc.contributor.author | Lynch, Aileen | en |
dc.contributor.author | Kelly, Aine | en |
dc.contributor.author | O'Neill, Luke | en |
dc.date.accessioned | 2009-09-30T21:59:10Z | |
dc.date.available | 2009-09-30T21:59:10Z | |
dc.date.issued | 2001 | en |
dc.date.submitted | 2001 | en |
dc.identifier.citation | Kelly ?, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA., The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, 49, 2001, 45564 - 45572 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/33696 | |
dc.description | PUBLISHED | en |
dc.description | PMID: 11581275 | en |
dc.description.abstract | Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these changes are an IL-1?-induced inhibition of long term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of glutamate release in synaptosomes prepared from the hippocampus. Evidence suggests that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain effects of IL-1. We investigated the effect of IL-10 on IL-1?-induced inhibition of LTP and glutamate release. The evidence presented indicates that IL-1? stimulates the stress-activated protein kinase, c-Jun-activated protein kinase (JNK), and IL-1 receptor-associated kinase, which may explain its inhibitory effect on release and LTP, and that IL-10 reversed the IL-1?-induced stimulation of JNK activity and inhibition of release and LTP. We observed that IL-10 abrogated the stimulatory effect of IL-1? on superoxide dismutase activity and reactive oxygen species production, whereas the H2O2-induced inhibition of LTP was also blocked by IL-10. We present evidence that suggests that the action of IL-10 may be mediated by its ability to induce shedding of the IL-1 type I receptor. | en |
dc.description.sponsorship | This work was supported by the Higher Education Authority (Ireland), European Union (EU) BioMed-2 Program Contract BMH4-CT97-2492, Enterprise Ireland, and the Health Research Board (Ireland). | en |
dc.format.extent | 45564 | en |
dc.format.extent | 45572 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.relation.ispartofseries | Journal of Biological Chemistry | en |
dc.relation.ispartofseries | 276 | en |
dc.relation.ispartofseries | 49 | en |
dc.rights | Y | en |
dc.subject | Physiology | en |
dc.title | The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/lynchma | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/aikelly | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/laoneill | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/amlynch | en |
dc.identifier.rssinternalid | 1714 | en |
dc.identifier.doi | http://dx.doi.org/10.1074/jbc.M108757200 | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.subject.TCDTheme | Neuroscience | en |
dc.identifier.rssuri | http://dx.doi.org/10.1074/jbc.M108757200 | |