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dc.contributor.authorLynch, Marinaen
dc.contributor.authorLynch, Aileenen
dc.contributor.authorKelly, Aineen
dc.contributor.authorO'Neill, Lukeen
dc.date.accessioned2009-09-30T21:59:10Z
dc.date.available2009-09-30T21:59:10Z
dc.date.issued2001en
dc.date.submitted2001en
dc.identifier.citationKelly ?, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA., The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, 49, 2001, 45564 - 45572en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/33696
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 11581275en
dc.description.abstractSeveral effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these changes are an IL-1?-induced inhibition of long term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of glutamate release in synaptosomes prepared from the hippocampus. Evidence suggests that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain effects of IL-1. We investigated the effect of IL-10 on IL-1?-induced inhibition of LTP and glutamate release. The evidence presented indicates that IL-1? stimulates the stress-activated protein kinase, c-Jun-activated protein kinase (JNK), and IL-1 receptor-associated kinase, which may explain its inhibitory effect on release and LTP, and that IL-10 reversed the IL-1?-induced stimulation of JNK activity and inhibition of release and LTP. We observed that IL-10 abrogated the stimulatory effect of IL-1? on superoxide dismutase activity and reactive oxygen species production, whereas the H2O2-induced inhibition of LTP was also blocked by IL-10. We present evidence that suggests that the action of IL-10 may be mediated by its ability to induce shedding of the IL-1 type I receptor.en
dc.description.sponsorshipThis work was supported by the Higher Education Authority (Ireland), European Union (EU) BioMed-2 Program Contract BMH4-CT97-2492, Enterprise Ireland, and the Health Research Board (Ireland).en
dc.format.extent45564en
dc.format.extent45572en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesJournal of Biological Chemistryen
dc.relation.ispartofseries276en
dc.relation.ispartofseries49en
dc.rightsYen
dc.subjectPhysiologyen
dc.titleThe anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNKen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lynchmaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aikellyen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/amlynchen
dc.identifier.rssinternalid1714en
dc.identifier.doihttp://dx.doi.org/10.1074/jbc.M108757200en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://dx.doi.org/10.1074/jbc.M108757200


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