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dc.contributor.authorMC LOUGHLIN, DECLANen
dc.date.accessioned2009-09-23T14:56:21Z
dc.date.available2009-09-23T14:56:21Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationMitchell JC, Ariff BB, Yates DM, Lau KF, Perkinton MS, Rogelj B, Stephenson JD, Miller CC, McLoughlin DM., X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice., Human Molecular Genetics, 18, 23, 2009, 4492-4500en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/33190
dc.descriptionPUBLISHEDen
dc.description.abstractIncreased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for Alzheimer?s disease. X11? is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP). Overexpression of X11? inhibits A? production in a number of experimental systems. However, whether these changes to APP processing and A? production induced by X11? overexpression also induce beneficial effects to memory and synaptic plasticity are not known. We report here that X11?-mediated reduction in cerebral A? is associated with normalisation of both cognition and in vivo long-term potentiation (LTP) in aged APPswe Tg2576 transgenic mice that model the amyloid pathology of Alzheimer?s disease. Overexpression of X11? itself has no detectable adverse effects upon mouse behaviour. These findings support the notion that modulation of X11? function represents a therapeutic target for A?-mediated neuronal dysfunction in Alzheimer?s disease.en
dc.description.sponsorshipThis work was supported by grants from the Wellcome Trust, the Alzheimer?s Society Medical Research Council, Alzheimer?s Association, Alzheimer?s Research Trust, European Union NeuroNE and The Health Foundation. We thank Gerald Finnerty (IoP King?s College London) for helpful discussions on electrophysiology.en
dc.format.extent4492-4500en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesHuman Molecular Geneticsen
dc.relation.ispartofseries18en
dc.relation.ispartofseries23en
dc.rightsYen
dc.subjectPsychiatryen
dc.titleX11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.en
dc.typeJournal Articleen
dc.contributor.sponsorWellcome Trusten
dc.contributor.sponsorMedical Research Council
dc.contributor.sponsorWellcome Trust
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclougdeen
dc.identifier.rssinternalid61605en
dc.identifier.rssurihttp://dx.doi.org/10.1093/hmg/ddp408
dc.identifier.rssurihttp://hmg.oxfordjournals.org/cgi/reprint/ddp408v1en


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