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dc.contributor.authorFALLON, PADRAIC
dc.date.accessioned2009-09-17T17:14:39Z
dc.date.available2009-09-17T17:14:39Z
dc.date.issued2004
dc.date.submitted2004en
dc.identifier.citationLanoue, A., Clatworthy, M.R., Smith, P. Green, S., Townsend, M.J., Jolin, H.E., Smith, K.G.S., Fallon, P.G. and McKenzie, A.N.J. `SIGN-R1 contributes to protection against lethal pneumococcal infection in mice? in Journal of Experimental Medicine, 200, (11), 2004, pp 1383 - 1393en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/32915
dc.descriptionPUBLISHEDen
dc.description.abstractRapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell?SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule.en
dc.description.sponsorshipP.G. Fallon is supported by the Wellcome Trust and Science Foundation, Ireland. P. Smith is supported by a grant from the Leukaemia Research Fund. M.R. Clatworthy is funded by a Wellcome Trust Clinical Training Fellowship (065770) and The Sackler Fund. K.G.C. Smith is supported by a Wellcome Research Leave Award for Clinical Academics (grant no. 067543AIA) and the Medical Research Council (grant no. 9805187).en
dc.format.extent4498050 bytes
dc.format.extent1383en
dc.format.extent1393en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherRockefeller University Pressen
dc.relation.ispartofseriesJournal of Experimental Medicineen
dc.relation.ispartofseries200en
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectDC-SIGN ? marginal zone macrophages ? microbial infection ? innate immunity ? lectinen
dc.titleSIGN-R1 contributes to protection against lethal pneumococcal infection in miceen
dc.typeJournal Articleen
dc.contributor.sponsorMedical Research Council
dc.contributor.sponsorWellcome Trust
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/pfallon
dc.identifier.rssinternalid25368
dc.identifier.rssurihttp://dx.doi.org/10.1084/jem.20040795


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