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dc.contributor.authorGILL, MICHAELen
dc.date.accessioned2009-07-07T09:43:50Z
dc.date.available2009-07-07T09:43:50Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationChristopher Doyle, Keeley Brookes, Jennifer Simpson, Joanne Park, Sarah Scott, David R. Coghill, Ziarah Hawi, Aiveen Kirley, Michael Gill and Lindsey Kent 'Replication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder' in Neuroscience Letters, 462, 2009, pp 179 - 181en
dc.identifier.otherYen
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/31369
dc.descriptionPUBLISHEDen
dc.description19576958en
dc.description.abstractGenetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multi-centre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three single nucleotide polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5? promoter region of the gene is significantly associated with ADHD (P = 0.02). This provides further evidence that in addition to the well-known and investigated 3?UTR polymorphism associated with ADHD, there is potentially a further association signal emanating from the 5? promoter region of the gene. Further replication and functional studies are now required to fully understand the consequence of polymorphisms present at both the 5? and 3? ends of the DAT1 gene and their role in ADHD pathophysiology.en
dc.format.extent244939 bytes
dc.format.extent179en
dc.format.extent181en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesNeuroscience Lettersen
dc.relation.ispartofseries462en
dc.rightsYen
dc.subjectADHD; DAT1; Association; Replication; Polymorphismen
dc.titleReplication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorderen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid59708en
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.neulet.2009.06.084


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