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dc.contributor.authorLAVELLE, EDWARDen
dc.contributor.authorMARTIN, SEAMUS JOSEPHen
dc.contributor.authorLUTHI, ALEXANDERen
dc.contributor.authorSHERIDAN, CLAREen
dc.date.accessioned2009-07-03T17:02:32Z
dc.date.available2009-07-03T17:02:32Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationAlexander U. Luthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, and Seamus J. Martin, Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases, Immunity, 31, 1, 2009, 84-98en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/31286
dc.descriptionIN_PRESSen
dc.description[PMID: 19559631 ]en
dc.description.abstractInterleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to the proinflammatory cytokines IL-1? and IL-18, but this remains unproven. Here we showed that IL-33 was processed by caspases activated during apoptosis (caspase-3 and -7) but was not a physiological substrate for caspases associated with inflammation (caspase-1, -4, and -5). Furthermore, caspase-dependent processing of IL-33 was not required for ST2 receptor binding or ST2-dependent activation of the NF-?B transcription factor. Indeed, caspase-dependent proteolysis of IL-33 dramatically attenuated IL-33 bioactivity in vitro and in vivo. These data suggest that IL-33 does not require proteolysis for activation, but rather, that IL-33 bioactivity is diminished through caspase-dependent proteolysis within apoptotic cells. Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33.en
dc.description.sponsorshipScience Foundation Ireland (PI1/B038) and The Health Research Board of Ireland (RP/2006/233)en
dc.format.extent84-98en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesImmunityen
dc.relation.ispartofseries31en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectMOLIMMUNO; CELLIMMUNOen
dc.titleSuppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspasesen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board
dc.contributor.sponsorScience Foundation Ireland
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/martinsjen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lavelleeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aluthien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sheridclen
dc.identifier.rssinternalid59644en
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.immuni.2009.05.007


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