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dc.contributor.authorGARAVAN, HUGH PATRICK
dc.date.accessioned2009-05-12T16:41:49Z
dc.date.available2009-05-12T16:41:49Z
dc.date.issued2009
dc.date.submitted2009en
dc.identifier.citationFassbender, C., Murphy, K., Hester, R., Foxe, J. J., Foxe, D. M., Javitt, D. C., & Garavan, H. `Prefrontal and midline interactions mediating behavioural control? in European Journal of Neuroscience, 29, 1, (2009), pp 181 - 187en
dc.identifier.issn0953-816X
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/30007
dc.descriptionPUBLISHEDen
dc.description.abstractTop-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.en
dc.format.extent181 - 187en
dc.format.extent395732 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.ispartofseriesEuropean Journal of Neuroscienceen
dc.relation.ispartofseries29en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectanterior cingulate cortex ? cognitive control ? dorsolateral prefrontal cortex ? fMRI ? human ? pre-supplementary motor areaen
dc.titlePrefrontal and midline interactions mediating behavioural control.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanh
dc.identifier.rssurihttp://dx.doi.org/10.1111/j.1460-9568.2008.06557.x


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